It is not uncommon for people with ulcerative colitis to feel fatigued. Fatigue refers to a state of being always tired and lacking energy. Fatigue can be mild or severe, depending on each person and the effects it has on the body. Ulcerative colitis, as well as its related symptoms such as anemia and dehydration, are often the leading causes of fatigue. To add to that, malnutrition can often worsen fatigue as well as overall health. Fatigue can be treated by addressing the main underlying issues. You can also try to improve your sleep quality at night to fight fatigue.