Most women who have their first migraine attack, experience one usually have it when they have their first period. Physical and physiological changes in women during their menstrual cycle can exacerbate migraine attacks. Such episodes are way more painful compared to regular migraine attacks. Women can feel extremely uncomfortable during migraine attacks and they can be really difficult to get rid of. The idea for avoiding migraine headache during periods would be to map your cycle and use pain medications to relieve the symptoms.